Disorders in microcirculation have been shown to be a key issue in a wide range of health problems including inflammation, cardiovascular disease and diabetes.

Reduced microcirculation is also an important factor in the cause of skin problems such as couperosa and cellulite. Couperosa is brought about by a disorder of facial circulation, or to be precise, the enlargement of small blood vessels. The enlarged blood vessels are visible through skin as a redness and thin reddish or bluish lines. Couperosa is generally seen in the case of thin, dry and delicate skin with capillaries located close to the skin surface. Thus couperosa is more frequently found in women, as men tend to have a thicker, stronger skin more resistant to environmental effects. Oxidative stress is often the major cause of damage to the microcirculation system. Antioxidants such as vitamin C and vitamin E as well as those found in grape seed, pine bark and blackcurrant have been shown to improve microcirculation.